GitHub View CyteType

Ranked pathway signals

How to use GO and WikiPathways enrichment ranked by NES in CyteType reports.

What it is

GO and WikiPathways enrichment results for each cluster, ranked by NES (Normalized Enrichment Score). Both up-regulated and down-regulated programs are shown.

How to read it

NES indicates strength and direction of pathway activation. Focus on pathways with |NES| > 1.5 for mechanistic interpretation. Use this to connect cell identity to cellular programs.

When to act

Unexpected pathway activation may indicate contamination, a stress response, or a biologically interesting subpopulation worth further investigation.

Learn more

Functional state resolution

Marker-level evidence